Comedolytic
Pronunciation: kom-ih-doh-LIT-ik
Describing an agent or property that dissolves or prevents the formation of comedones, particularly in the treatment of acne vulgaris.
Full Definition
The term 'comedolytic' is an adjective applied to topical and systemic agents — such as retinoids and salicylic acid — that act on the follicular infundibulum to prevent keratin plug formation or disrupt existing comedones. It is distinct from 'comedogenic', which describes agents that promote comedone formation. Editors frequently encounter this pair as a confusable; 'comedolytic' (breaking down) and 'comedogenic' (causing formation) are near-antonyms. The suffix '-lytic' (dissolving) should not be confused with '-genic' (producing).
Usage
Usage note: Do not confuse with 'comedogenic'. Ensure the correct suffix is present before finalising copy. No hyphen.
In Context
- "Adapalene 0.1% gel was selected for its well-established comedolytic and anti-inflammatory properties." — Acne treatment protocol
- "The cosmetic formulation was tested to confirm its comedolytic activity before inclusion in the study arm." — Clinical trial protocol