Dermatitis Herpetiformis
Pronunciation: der-mah-TY-tis her-PET-ih-FOR-miss
An intensely pruritic, chronic blistering skin condition associated with gluten sensitivity and coeliac disease. Editors should note both words are capitalised only when used as a proper diagnosis.
Full Definition
Dermatitis herpetiformis (DH) is a chronic, autoimmune vesiculobullous dermatosis characterised by intensely itchy papules and vesicles symmetrically distributed over the elbows, knees, buttocks, and scalp. It is strongly associated with coeliac disease due to IgA antibodies reacting to epidermal transglutaminase. Despite the name, it is not caused by the herpes virus; the 'herpetiformis' descriptor refers to the grouped (herpetiform) arrangement of lesions. Diagnosis is confirmed by direct immunofluorescence of perilesional skin. Editors must ensure the name is not confused with herpes simplex or herpes zoster in clinical documents.
Usage
Usage note: Not related to herpes viruses; editors should flag any manuscript that implies a viral aetiology for this condition.
In Context
- "A gluten-free diet remains the cornerstone of long-term management for dermatitis herpetiformis." — Patient management guideline
- "Direct immunofluorescence confirmed the diagnosis of dermatitis herpetiformis with granular IgA deposits." — Histopathology report