Keratinocyte
Pronunciation: keh-RAT-ih-no-syte
The predominant cell type of the epidermis, responsible for producing keratin and forming the protective skin barrier.
Full Definition
Keratinocytes constitute approximately 90% of epidermal cells and undergo a continuous process of differentiation (keratinisation) as they migrate from the stratum basale to the stratum corneum. They produce structural proteins including keratins and filaggrin, which are essential for the epidermal barrier function. Disruption of keratinocyte biology underlies many dermatological conditions, including psoriasis, atopic dermatitis, and various genodermatoses. Editors must distinguish 'keratinocyte' from 'corneocyte' (the terminally differentiated, anucleate end-stage cell in the stratum corneum) in histopathology and molecular dermatology manuscripts.
Usage
Usage note: Distinguish from 'corneocyte', the terminally differentiated form found only in the stratum corneum, which lacks a nucleus.
In Context
- "In vitro studies showed that the compound significantly inhibited keratinocyte proliferation at nanomolar concentrations." — Basic science/research manuscript
- "The editor queried whether the author intended 'keratinocyte' or 'corneocyte' when describing the outermost cell layer." — Manuscript query sheet