BRMS1
Also written as: BRMS1 — breast cancer metastasis suppressor 1
Breast cancer metastasis suppressor 1, a gene that regulates cancer cell invasion and metastatic potential.
Full Definition
BRMS1 (breast cancer metastasis suppressor 1) is a gene that encodes a protein involved in suppressing metastatic spread of cancer cells. Originally identified in breast cancer research, BRMS1 expression levels correlate with metastatic potential across multiple cancer types. Low BRMS1 expression is associated with increased risk of metastasis, while high expression suggests better prognosis. The gene functions through regulation of gene transcription and chromatin remodeling. In clinical documentation, BRMS1 status may inform prognosis and treatment decisions.
Usage
Usage note: Not to be confused with BRCA genes - BRMS1 relates to metastasis suppression, not hereditary cancer risk.
In Context
- "Tumor analysis revealed decreased BRMS1 expression consistent with aggressive phenotype." — Pathology report
- "BRMS1 status was included in the molecular profiling panel for prognostic assessment." — Laboratory requisition