desmoplastic reaction
Pronunciation: DEZ-mo-PLAS-tik
The formation of fibrous connective tissue around a tumor, creating a dense stromal response.
Full Definition
A desmoplastic reaction refers to the proliferation of fibrous connective tissue and collagen deposition that occurs in response to malignant infiltration. This stromal response creates a dense, firm texture around the tumor and can be palpated clinically or visualized on imaging studies. Desmoplastic reactions are particularly characteristic of certain tumor types, including pancreatic adenocarcinoma, invasive breast carcinoma, and some sarcomas. The fibrotic response can make surgical resection more challenging and may affect drug penetration into the tumor. Pathologically, this reaction helps distinguish invasive carcinoma from in situ disease.
Usage
Usage note: Commonly misspelled as 'desmoplasic'. The term describes both the process and the resulting tissue characteristics.
In Context
- "The pancreatic mass demonstrated marked desmoplastic reaction on both CT and surgical exploration." — Pathology report
- "Invasive ductal carcinoma with extensive desmoplastic reaction was noted in the breast biopsy specimen." — Histopathology findings