grade 3
Severe adverse event classification requiring medical intervention or hospitalization.
Full Definition
Grade 3 represents severe adverse events in the Common Terminology Criteria for Adverse Events (CTCAE) grading system, indicating symptoms that are severe or medically significant but not immediately life-threatening. Grade 3 events typically require hospitalization, prolongation of existing hospitalization, or urgent medical intervention. These events may substantially interfere with activities of daily living and often necessitate treatment modification, dose reduction, or temporary treatment discontinuation. Grade 3 toxicities are closely monitored in clinical trials as they represent the threshold for clinically significant treatment-related harm.
Usage
Usage note: Always specify the adverse event type when reporting grade 3 toxicity.
In Context
- "Grade 3 diarrhea occurred in 12% of patients receiving the combination regimen." — Safety analysis report
- "Treatment was held for grade 3 neutropenia until recovery to grade 1 or better." — Protocol dose modification guidelines