lymphovascular invasion
Also written as: LVI — lymphovascular invasion
Presence of tumor cells within lymphatic or blood vessel spaces, indicating increased metastatic potential.
Full Definition
Lymphovascular invasion (LVI) refers to the presence of tumor cells within the lumens of lymphatic vessels or blood vessels. This pathological finding indicates that cancer cells have breached the basement membrane and gained access to the circulatory system, representing a critical step in the metastatic process. LVI is an important prognostic factor across multiple cancer types, associated with increased risk of lymph node metastases and distant recurrence. The presence of LVI often influences staging, prognosis, and adjuvant treatment decisions. Pathologists specifically examine tissue specimens for this feature using standard histological techniques.
Usage
Usage note: May be abbreviated as LVI. Distinguish from lymph node metastases which represents established spread.
In Context
- "Pathology showed extensive lymphovascular invasion concerning for metastatic potential." — Pathology report
- "The presence of LVI upgraded the patient's risk category for adjuvant therapy." — Multidisciplinary team notes