analyte
Pronunciation: /ˈænəlaɪt/
The specific biochemical substance measured in newborn screening tests to detect metabolic or genetic disorders.
Full Definition
An analyte in newborn screening is any measurable biochemical compound used as a marker for genetic or metabolic disorders. Common analytes include amino acids, organic acids, fatty acids, enzymes, hormones, and immunoreactive substances. Each analyte serves as either a direct marker of a specific disorder or as part of a ratio calculation that enhances diagnostic accuracy. The selection and measurement of appropriate analytes form the foundation of screening algorithms, with cutoff values established through population studies and clinical validation.
Usage
Usage note: Plural form is 'analytes'; avoid confusion with 'analyst' (the person performing analysis).
In Context
- "The analyte concentration exceeded the established cutoff, triggering a positive screen result." — laboratory report
- "New analytes are continuously evaluated for inclusion in expanded screening panels." — research publication