flow injection analysis
Also written as: FIA — Flow Injection Analysis
Automated analytical technique used in newborn screening for rapid, sequential measurement of metabolites in dried blood spots.
Full Definition
Flow injection analysis (FIA) is an automated analytical chemistry technique widely used in newborn screening laboratories for rapid, precise measurement of metabolites and other biomarkers. The technique involves injecting sample extracts into a continuously flowing carrier stream that transports the sample through a series of analytical reactions and detection systems. In tandem mass spectrometry applications, FIA enables rapid sample introduction without chromatographic separation, significantly reducing analysis time compared to liquid chromatography methods. This approach is particularly valuable for high-throughput newborn screening where laboratories must process thousands of samples daily while maintaining analytical quality and rapid turnaround times.
Usage
Usage note: Commonly abbreviated as FIA in technical literature; hyphenate when used as compound modifier.
In Context
- "Flow injection analysis methods enable processing of over 1000 samples per day." — Laboratory capacity report
- "The laboratory optimized flow injection analysis parameters to minimize carryover effects." — Method development protocol