lyophilized
Pronunciation: /laɪˈɒfɪlaɪzd/
Freeze-dried state of reference materials or quality control samples used in newborn screening assays for enhanced stability.
Full Definition
Lyophilized materials in newborn screening are freeze-dried preparations of blood-based reference materials, calibrators, or quality control samples that provide enhanced stability and extended shelf life. The lyophilization process removes water while preserving the biological activity of analytes, allowing these materials to be stored at room temperature and shipped worldwide without refrigeration. Before use, lyophilized materials are reconstituted with appropriate solutions to restore their original properties. These materials are essential for standardizing analytical methods and ensuring consistent performance across laboratories.
Usage
Usage note: American spelling uses 'z', British spelling uses 's' (lyophilised); past tense and adjective forms are identical.
In Context
- "The lyophilized quality control material was reconstituted according to manufacturer instructions." — laboratory procedure
- "Lyophilized calibrators provide excellent long-term stability for amino acid analysis." — analytical validation