metabolic stress
The physiological challenge that reveals underlying metabolic disorders during the transition from placental to independent metabolism.
Full Definition
Metabolic stress in newborn screening refers to the normal physiological challenges that occur when infants transition from receiving nutrients through the placenta to independent feeding and metabolism. This stress reveals many inherited metabolic disorders that might otherwise remain undetected during fetal development. The stress includes factors such as the onset of protein catabolism, changes in hormone levels, initiation of feeding, and the body's response to environmental temperature changes. Timing of sample collection relative to this metabolic stress is crucial for optimal screening sensitivity.
Usage
Usage note: Use as a compound noun; avoid hyphenation unless used as a compound modifier.
In Context
- "Adequate metabolic stress is essential for detecting carnitine cycle disorders in newborn screening." — clinical guideline
- "Samples collected too early may miss disorders that only become apparent under metabolic stress." — screening protocol