tocolysis
Pronunciation: toh-KOL-ih-sis
Medical intervention to stop or slow preterm labor contractions.
Full Definition
Tocolysis involves the use of medications (tocolytics) to inhibit uterine contractions and delay preterm delivery. Common tocolytic agents include nifedipine, terbutaline, magnesium sulfate, and indomethacin, each working through different mechanisms to reduce uterine muscle activity. Tocolysis is typically considered when preterm labor occurs between 24-34 weeks gestation to allow time for administration of antenatal corticosteroids to accelerate fetal lung maturity and, if necessary, transfer to a facility with appropriate neonatal care capabilities. The goal is to delay delivery for 48-72 hours rather than prevent preterm birth entirely. Success rates and side effects vary depending on the specific medication used and clinical circumstances.
Usage
Usage note: Distinguish from tocodynamometry (measurement of uterine contractions); tocolytic drugs are the agents used.
In Context
- "Tocolysis was initiated with nifedipine to delay delivery and allow steroid administration." — obstetric consultation
- "The effectiveness of tocolysis varies depending on gestational age and underlying cause of preterm labor." — research publication