unconjugated hyperbilirubinemia
Pronunciation: hy-per-bil-ih-roo-bih-NEE-mee-ah
Elevated levels of indirect bilirubin in the blood, the predominant form of neonatal jaundice.
Full Definition
An elevation of indirect (unconjugated) bilirubin in the bloodstream, which is the most common cause of visible jaundice in newborns. Unconjugated bilirubin is lipophilic and can cross the blood-brain barrier, potentially causing kernicterus at very high levels. This form of hyperbilirubinemia typically results from increased bilirubin production, decreased hepatic uptake, or impaired conjugation. It responds to phototherapy and differs from conjugated hyperbilirubinemia, which suggests more serious hepatic or biliary pathology.
Usage
Usage note: Distinguish clearly from conjugated form; specify direct and indirect bilirubin levels.
In Context
- "Laboratory results showed unconjugated hyperbilirubinemia with total bilirubin of 15 mg/dL and direct fraction of 0.8 mg/dL." — Laboratory interpretation
- "The infant's unconjugated hyperbilirubinemia responded well to intensive phototherapy treatment." — Treatment response note