Professional
Technical
In the Industry Vocabulary Test
1p/19q codeletion
Pronunciation: one-p-nineteen-q co-deletion
Chromosomal abnormality involving loss of chromosome arms 1p and 19q, characteristic of oligodendrogliomas.
Full Definition
1p/19q codeletion is a specific chromosomal abnormality characterized by the concurrent loss of the short arm of chromosome 1 (1p) and the long arm of chromosome 19 (19q). This genetic alteration is pathognomonic for oligodendrogliomas and is associated with chemosensitivity and improved survival. The presence of 1p/19q codeletion, along with IDH mutation, defines the molecular signature of oligodendrogliomas in the current WHO classification system.
Usage
Usage note: Must be written with forward slash; codeletion should be one word.
In Context
- "FISH analysis confirmed 1p/19q codeletion, consistent with the morphological diagnosis of oligodendroglioma." — Molecular pathology report
- "The tumor showed classic oligodendroglial features and tested positive for 1p/19q codeletion." — Neuropathology consultation
Also known as
chromosome 1p/19q loss
1p19q codeletion
Contrasted with
1p/19q intact
Don't confuse with
1p deletion alone
19q deletion alone