Intermediate
Technical
In the Industry Vocabulary Test
cortical dysplasia
Developmental malformation of cerebral cortex characterized by abnormal neuronal organization and architecture.
Full Definition
Cortical dysplasia, also known as focal cortical dysplasia (FCD), is a developmental malformation of the cerebral cortex characterized by abnormal neuronal migration, differentiation, and cortical organization. These lesions are classified into several types based on histological features, including architectural disruption, cytological abnormalities, and the presence of balloon cells. Cortical dysplasia is a leading cause of pharmacoresistant epilepsy and requires careful histopathological evaluation to guide surgical treatment decisions.
Usage
Usage note: Specify dysplasia type (I, II, III) when classified; often abbreviated as FCD.
In Context
- "The resected tissue showed Type IIB cortical dysplasia with prominent balloon cells and architectural disorganization." — Epilepsy surgery pathology
- "Subtle cortical dysplasia was identified as the epileptogenic focus in this pediatric patient." — Pediatric neuropathology
Also known as
focal cortical dysplasia
FCD
cortical malformation
Contrasted with
normal cortical architecture
Don't confuse with
cortical sclerosis
cortical atrophy