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MGMT promoter methylation
Epigenetic silencing of the DNA repair gene MGMT, serving as a predictive biomarker for alkylating agent chemotherapy response.
Full Definition
MGMT promoter methylation refers to the hypermethylation of the promoter region of the O6-methylguanine-DNA methyltransferase (MGMT) gene, which results in reduced expression of this DNA repair enzyme. This epigenetic modification is a crucial predictive biomarker in glioblastoma treatment, as tumors with methylated MGMT promoters show enhanced sensitivity to alkylating agents like temozolomide. The methylation status significantly influences treatment decisions and patient prognosis.
Usage
Usage note: Always specify 'promoter' to distinguish from protein methylation; use standard abbreviation MGMT.
In Context
- "The glioblastoma showed MGMT promoter methylation, indicating likely response to temozolomide therapy." — Molecular pathology report
- "Testing for MGMT promoter methylation status is essential for treatment planning in newly diagnosed glioblastoma." — Clinical guideline
Also known as
MGMT methylation status
MGMT hypermethylation
Contrasted with
MGMT promoter unmethylated
Don't confuse with
MGMT expression
MGMT protein level