telomerase reverse transcriptase
Also written as: TERT — Telomerase Reverse Transcriptase
Enzyme component whose promoter mutations are significant molecular markers in CNS tumors. TERT promoter status helps classify gliomas and determine prognosis.
Full Definition
Telomerase reverse transcriptase (TERT) is the catalytic subunit of the telomerase enzyme complex responsible for maintaining telomere length. In neuropathology, mutations in the TERT promoter region have emerged as crucial molecular markers for central nervous system tumor classification and prognosis. TERT promoter mutations are commonly found in IDH-wildtype glioblastomas and IDH-mutant 1p/19q-codeleted oligodendrogliomas, where they serve as important diagnostic and prognostic indicators. The presence or absence of these mutations, combined with other molecular markers, helps pathologists accurately classify tumors according to current WHO guidelines and provide relevant prognostic information to clinicians.
Usage
Usage note: Commonly abbreviated as TERT in clinical reports, but spell out on first use in formal documents.
In Context
- "TERT promoter mutation analysis was positive, supporting the diagnosis of oligodendroglioma." — Molecular pathology report
- "The tumor showed IDH1 mutation and intact 1p/19q with concurrent TERT promoter mutation." — Integrated diagnosis report