glioblastoma
Pronunciation: /ˌɡlaɪoʊblæˈstoʊmə/
Highly malignant primary brain tumor arising from glial cells, representing the most aggressive form of glioma.
Full Definition
Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, arising from glial cells and classified as a Grade IV astrocytoma according to WHO criteria. These tumors are characterized by rapid growth, high cellularity, microvascular proliferation, and necrosis. Glioblastomas typically present with ring enhancement on contrast-enhanced imaging and surrounding vasogenic edema. The prognosis is poor, with median survival typically measured in months despite aggressive multimodal treatment including surgery, radiation, and chemotherapy. Neuroimaging plays a crucial role in diagnosis, treatment planning, and monitoring response to therapy.
Usage
Usage note: May be abbreviated as GBM; avoid outdated term 'glioblastoma multiforme' in current usage.
In Context
- "The MRI findings were highly suggestive of glioblastoma with characteristic ring enhancement." — Radiology report
- "Glioblastoma should be differentiated from solitary brain metastases on imaging." — Differential diagnosis