periventricular leukomalacia
Pronunciation: pair-ih-ven-TRIK-yoo-lar loo-ko-mah-LAY-shah
Also written as: PVL — periventricular leukomalacia
White matter injury near the ventricles, commonly seen in premature infants and associated with cerebral palsy.
Full Definition
Periventricular leukomalacia (PVL) is a form of white matter brain injury that occurs predominantly in premature infants. It involves necrosis or loss of white matter near the lateral ventricles, particularly in watershed areas with vulnerable blood supply. PVL is a leading cause of cerebral palsy and cognitive impairment in survivors of premature birth. On neuroimaging, it appears as cystic changes or gliosis in the periventricular white matter, often with associated ventricular enlargement.
Usage
Usage note: Distinguish from general leukomalacia and periventricular hemorrhage in editorial contexts.
In Context
- "MRI demonstrated bilateral periventricular leukomalacia with associated ex vacuo ventricular dilatation." — Pediatric radiology report
- "The patient's developmental delays are consistent with a history of severe periventricular leukomalacia." — Clinical correlation note