subependymal giant cell astrocytoma
Also written as: SEGA — subependymal giant cell astrocytoma
Benign tumor arising near ventricular wall, typically associated with tuberous sclerosis complex.
Full Definition
Subependymal giant cell astrocytoma (SEGA) is a slow-growing, WHO grade I tumor that typically arises from subependymal nodules near the foramen of Monro in patients with tuberous sclerosis complex. These tumors demonstrate mixed signal intensity on MRI with areas of enhancement following contrast administration. The location near the foramen of Monro can lead to obstructive hydrocephalus as the tumor enlarges. Unlike typical astrocytomas, SEGAs have a favorable prognosis with surgical resection being curative. They may show calcification and can be distinguished from subependymal nodules by their size (typically >1cm) and growth over time.
Usage
Usage note: Always consider tuberous sclerosis complex in the differential when SEGA is suspected.
In Context
- "A subependymal giant cell astrocytoma was identified at the left foramen of Monro causing hydrocephalus." — Tuberous sclerosis surveillance
- "Serial imaging showed growth of the subependymal nodule, now consistent with SEGA." — Pediatric neuro-oncology report