white matter hyperintensity
Also written as: WMH — White Matter Hyperintensity
Areas of increased signal in white matter on T2/FLAIR imaging, often related to small vessel disease or aging.
Full Definition
White matter hyperintensities (WMH) appear as areas of increased signal intensity on T2-weighted and FLAIR sequences, typically in the periventricular and deep white matter regions. These lesions are commonly associated with aging, hypertension, diabetes, and other vascular risk factors, representing chronic small vessel disease and demyelination. WMH burden is often quantified using standardized scales and correlates with cognitive decline and increased stroke risk. The distribution pattern can help distinguish between different etiologies of white matter disease.
Usage
Usage note: Graded using Fazekas or other standardized scales.
In Context
- "Moderate periventricular white matter hyperintensities were consistent with chronic small vessel disease." — elderly patient MRI report
- "The pattern of white matter hyperintensities suggested vascular rather than inflammatory etiology." — dementia workup