leptomeningeal enhancement
Pronunciation: LEP-toe-men-IN-jee-al
Abnormal contrast uptake in the brain's thin meningeal layers on MRI, indicating inflammation or malignant infiltration.
Full Definition
Leptomeningeal enhancement refers to the pathological uptake of contrast material in the pia mater and arachnoid mater, the two innermost layers of the meninges, as visualized on contrast-enhanced magnetic resonance imaging. This finding can indicate various pathological processes including infectious meningitis, autoimmune conditions, or malignant processes such as leptomeningeal carcinomatosis or lymphomatosis. The enhancement pattern may be linear, nodular, or diffuse, and its distribution and characteristics can provide important diagnostic clues. Associated clinical symptoms often include headache, altered mental status, and focal neurological deficits.
Usage
Usage note: Specify enhancement pattern (linear, nodular, or diffuse) and distribution to aid in differential diagnosis.
In Context
- "Post-contrast MRI revealed diffuse leptomeningeal enhancement concerning for carcinomatous meningitis." — Neuro-oncology consultation report