vasogenic edema
Brain swelling caused by breakdown of the blood-brain barrier, allowing fluid accumulation in the extracellular white matter space.
Full Definition
Vasogenic edema occurs when the integrity of the blood-brain barrier is compromised, leading to leakage of plasma proteins and fluid into the extracellular space of brain tissue. This type of edema predominantly affects white matter and is commonly associated with brain tumors, abscesses, traumatic brain injury, and inflammatory conditions. Unlike cytotoxic edema, vasogenic edema responds well to corticosteroid therapy and osmotic agents. On imaging studies, vasogenic edema appears as areas of increased T2 and FLAIR signal intensity that typically spare gray matter structures and may demonstrate mass effect requiring surgical intervention.
Usage
Usage note: Distinguish from cytotoxic edema, which involves cellular swelling and does not respond to steroids.
In Context
- "MRI revealed extensive vasogenic edema surrounding the right parietal mass lesion with significant midline shift." — Neuroimaging report