excitatory postsynaptic potential
Also written as: EPSP — excitatory postsynaptic potential
Depolarizing electrical response in a postsynaptic neuron caused by neurotransmitter binding.
Full Definition
An excitatory postsynaptic potential (EPSP) is a temporary depolarization of the postsynaptic membrane potential caused by the binding of excitatory neurotransmitters to their receptors. EPSPs bring the membrane potential closer to the threshold for action potential generation. Multiple EPSPs can summate temporally or spatially to reach the threshold for firing. The amplitude and duration of EPSPs depend on the type and number of receptors activated, the amount of neurotransmitter released, and the membrane properties of the postsynaptic cell. EPSPs are fundamental to neural computation and information processing.
Usage
Usage note: Commonly abbreviated as EPSP; contrast with IPSP.
In Context
- "The EPSP amplitude decreased following the application of the glutamate antagonist." — Electrophysiology report
- "Summation of multiple EPSPs triggered an action potential in the recorded neuron." — Research findings