postsynaptic density
Also written as: PSD — postsynaptic density
Protein-rich region beneath the postsynaptic membrane containing receptors and signaling molecules.
Full Definition
The postsynaptic density (PSD) is a specialized protein complex located directly beneath the postsynaptic membrane at excitatory synapses. It contains glutamate receptors, scaffolding proteins, and signaling enzymes that are crucial for synaptic transmission and plasticity. The PSD serves as a molecular platform for organizing synaptic proteins and is dynamic, changing its composition in response to synaptic activity. Understanding PSD structure and function is essential for comprehending synaptic plasticity mechanisms and neurological disorders involving synaptic dysfunction.
Usage
Usage note: Often abbreviated as PSD in neuroscience literature.
In Context
- "The postsynaptic density was enriched with NMDA receptors following the plasticity protocol." — Research manuscript
- "PSD-95 is a key scaffolding protein within the postsynaptic density." — Scientific review