neuroendocrine hyperplasia
Abnormal increase in the number of neuroendocrine cells within a tissue, often preceding neoplastic transformation.
Full Definition
Neuroendocrine hyperplasia represents a pathological condition characterized by an increased number of neuroendocrine cells within a given tissue or organ. This condition may be reactive, secondary to chronic inflammation or hormonal stimulation, or it may represent a pre-neoplastic lesion that can progress to neuroendocrine tumor formation. The hyperplasia can be diffuse throughout the tissue or form discrete nodular collections. Diagnosis requires careful morphological assessment and often involves quantitative analysis of neuroendocrine cell density using specific immunohistochemical markers. The clinical significance varies depending on the anatomical site and underlying cause.
Usage
Usage note: Distinguish from neuroendocrine neoplasia, which implies clonal proliferation rather than reactive increase.
In Context
- "Chronic hypergastrinemia led to diffuse neuroendocrine hyperplasia in the gastric fundus." — pathology report
- "The bronchial biopsy showed neuroendocrine hyperplasia that was considered a precursor lesion to carcinoid tumor development." — clinical case report