Intermediate
Technical
IVT
somatostatin
Pronunciation: so-ma-to-STAT-in
Inhibitory peptide hormone that suppresses growth hormone release and has widespread regulatory effects throughout the body.
Full Definition
Somatostatin is a cyclic peptide hormone that exists in two main forms: somatostatin-14 and somatostatin-28. Originally discovered as a growth hormone-inhibiting factor, somatostatin is produced by hypothalamic neurons and also by D-cells in the pancreas and gastrointestinal tract. It acts through G-protein coupled receptors to inhibit hormone secretion, including growth hormone, insulin, and glucagon, and also affects neurotransmission.
Usage
Usage note: Functions as inhibitory hormone; contrast with stimulatory releasing hormones.
In Context
- "Somatostatin analogs are used to treat acromegaly and neuroendocrine tumors." — Pharmacotherapy review
- "The patient showed elevated somatostatin levels consistent with pancreatic islet cell dysfunction." — Laboratory report
Also known as
SRIF
growth hormone-inhibiting hormone
Contrasted with
growth hormone-releasing hormone
Don't confuse with
growth hormone
somatomammotropin