Zollinger-Ellison syndrome
Pronunciation: ZOL-in-jer EL-i-son
A clinical syndrome caused by gastrin-secreting tumors resulting in peptic ulcer disease and gastric acid hypersecretion.
Full Definition
Zollinger-Ellison syndrome (ZES) is characterized by gastric acid hypersecretion due to excessive gastrin release from neuroendocrine tumors, typically gastrinomas. The syndrome manifests with recurrent peptic ulcers, often in unusual locations, secretory diarrhea, and malabsorption. Most gastrinomas associated with ZES are located within the gastrinoma triangle, encompassing the pancreatic head, duodenum, and associated lymph nodes. Approximately 25% of cases occur in association with MEN1 syndrome. Treatment involves both acid suppression with proton pump inhibitors and management of the underlying tumor through surgical resection or medical therapy.
Usage
Usage note: Named after the physicians who first described the syndrome in 1955.
In Context
- "The combination of refractory peptic ulcers and elevated gastrin levels suggested Zollinger-Ellison syndrome." — Gastroenterology consultation
- "High-dose proton pump inhibitor therapy was initiated for Zollinger-Ellison syndrome management." — Treatment plan