CLIPPERS

Full Definition

CLIPPERS (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) is a rare inflammatory disorder of the central nervous system characterized by T-cell infiltration around blood vessels in the brainstem, particularly the pons. The condition presents with progressive neurological symptoms and distinctive neuroimaging findings showing punctate enhancement in a 'salt and pepper' pattern. The disorder is notable for its dramatic response to corticosteroid therapy, though long-term immunosuppression is typically required.

Usage

Usage note: Always capitalize as CLIPPERS; the acronym is more commonly used than the full name.

In Context

• "The characteristic salt and pepper enhancement pattern on post-gadolinium imaging suggested CLIPPERS syndrome." — Neuroradiology report
• "Brain biopsy confirmed the diagnosis of CLIPPERS with typical perivascular lymphocytic infiltration." — Pathology report