HLA-DRB1
Pronunciation: H-L-A D-R-B-one
Also written as: HLA-DRB1 — Human Leukocyte Antigen DR Beta 1
Human leukocyte antigen gene strongly associated with multiple sclerosis susceptibility and disease course.
Full Definition
HLA-DRB1 is a gene within the major histocompatibility complex that encodes class II human leukocyte antigen molecules crucial for antigen presentation to T cells. Specific alleles of HLA-DRB1, particularly DRB1*15:01, are strongly associated with increased susceptibility to multiple sclerosis and other autoimmune neurological diseases. The HLA-DRB1 genotype can influence disease severity, response to therapy, and risk of developing secondary autoimmune conditions. Understanding HLA associations is important for risk stratification, treatment selection, and genetic counseling in neuroinflammatory diseases.
Usage
Usage note: Always hyphenate and capitalize. Include allele designation when relevant (e.g., HLA-DRB1*15:01).
In Context
- "Genetic testing revealed the presence of HLA-DRB1*15:01, increasing the patient's risk for multiple sclerosis." — Genetic counseling report
- "HLA-DRB1 typing may inform treatment decisions in patients with demyelinating disease." — Clinical genetics review