leukocyte trafficking
The regulated movement of white blood cells from circulation into CNS tissue through blood-brain barrier checkpoints.
Full Definition
Leukocyte trafficking refers to the highly regulated process by which white blood cells migrate from the systemic circulation into central nervous system tissues. This multi-step process involves selectin-mediated rolling, chemokine-mediated activation, integrin-mediated firm adhesion, and transmigration across the blood-brain barrier or blood-CSF barrier. Under physiological conditions, leukocyte trafficking into the CNS is minimal due to the barrier properties and immunoprivileged status. However, during neuroinflammation, this process becomes dysregulated, allowing pathogenic immune cells to enter and contribute to tissue damage. Understanding leukocyte trafficking mechanisms has led to important therapeutic targets.
Usage
Usage note: Prefer 'trafficking' over 'trafficking' in scientific contexts.
In Context
- "Dysregulated leukocyte trafficking across the blood-brain barrier was evident in the neuroinflammatory lesions." — Pathology report
- "The therapeutic drug specifically targets molecules involved in leukocyte trafficking to reduce CNS inflammation." — Pharmacology study