1p/19q codeletion
Pronunciation: one-p nineteen-q co-deletion
Chromosomal alteration involving loss of chromosome arms 1p and 19q, defining oligodendrogliomas.
Full Definition
1p/19q codeletion refers to the simultaneous loss of the short arm of chromosome 1 and the long arm of chromosome 19, which is the molecular hallmark of oligodendroglial tumors. This genetic alteration results from an unbalanced translocation and is associated with better treatment response and improved patient survival. The codeletion status, along with IDH mutation, is now mandatory for oligodendroglioma diagnosis according to current WHO criteria, representing the integration of molecular markers into brain tumor classification.
Usage
Usage note: Use forward slash between chromosomal arms; 'codeletion' is one word.
In Context
- "FISH analysis confirmed 1p/19q codeletion in this IDH-mutant tumor." — Molecular diagnostics report
- "The presence of 1p/19q codeletion supports the diagnosis of oligodendroglioma, WHO grade II." — Brain tumor classification