Lewy body
Cytoplasmic inclusion bodies containing alpha-synuclein, characteristic of Parkinson's disease and related disorders.
Full Definition
Lewy bodies are distinctive eosinophilic cytoplasmic inclusion bodies found in neurons affected by synucleinopathies, most notably Parkinson's disease and dementia with Lewy bodies. These spherical structures contain aggregated alpha-synuclein protein along with other components including ubiquitin and neurofilament proteins. Classical Lewy bodies have a dense core surrounded by a pale halo, while cortical Lewy bodies may appear less structured. The distribution pattern of Lewy bodies throughout the nervous system follows predictable stages and is crucial for staging Parkinson's disease pathology and differentiating between related neurodegenerative conditions.
Usage
Usage note: Capitalize as it's an eponymous term; distinguish between classical brainstem and cortical types.
In Context
- "Classical Lewy bodies were identified in substantia nigra neurons using alpha-synuclein immunostaining." — Autopsy findings
- "The cortical Lewy body pathology was consistent with dementia with Lewy bodies." — Neuropathological diagnosis