neurofibrillary tangle
Pronunciation: noo-roh-FIB-ri-lar-ee TANG-gul
Also written as: NFT — Neurofibrillary Tangle
Intracellular protein aggregates composed of hyperphosphorylated tau, a hallmark pathological feature of Alzheimer's disease.
Full Definition
Neurofibrillary tangles (NFTs) are abnormal intracellular accumulations of hyperphosphorylated tau protein that form twisted filaments within neurons. They are one of the two major pathological hallmarks of Alzheimer's disease, along with amyloid plaques. NFTs are also found in other neurodegenerative disorders collectively termed tauopathies. The distribution and density of neurofibrillary tangles correlates with cognitive decline and is used for staging Alzheimer's disease pathology according to Braak criteria. Editors should distinguish NFTs from other protein aggregates and understand their diagnostic significance in neuropathological contexts.
Usage
Usage note: Distinguish from extracellular protein aggregates; specify staining method and anatomical location.
In Context
- "Silver staining revealed abundant neurofibrillary tangles in the entorhinal cortex." — Alzheimer's disease autopsy report
- "The Braak stage was determined by the distribution of neurofibrillary tangles." — Neuropathological staging report