Pick body
Tau-containing cytoplasmic inclusions characteristic of Pick's disease and frontotemporal dementia.
Full Definition
Pick bodies are distinctive argyrophilic cytoplasmic inclusion bodies found in neurons affected by Pick's disease, a specific form of frontotemporal dementia. These round to oval structures contain hyperphosphorylated tau protein arranged in a different conformation than that seen in Alzheimer's disease. Pick bodies are most commonly found in the frontal and temporal cortices and can be demonstrated using silver stains or tau immunohistochemistry. Their presence, along with the characteristic pattern of frontotemporal atrophy and specific tau isoform composition, helps distinguish Pick's disease from other tauopathies and neurodegenerative conditions.
Usage
Usage note: Capitalize as eponymous term; distinguish from other tau inclusions by morphology and distribution.
In Context
- "Numerous Pick bodies were identified in pyramidal neurons of the frontal cortex." — Neuropathological examination
- "The presence of Pick bodies confirmed the diagnosis of Pick's disease rather than other frontotemporal dementias." — Diagnostic conclusion