Professional
Technical
IVT
anticholinergic burden
The cumulative effect of medications that block acetylcholine receptors, potentially causing cognitive impairment and other side effects.
Full Definition
Anticholinergic burden refers to the cumulative pharmacological load from medications that antagonize acetylcholine receptors in the brain and peripheral nervous system. This burden is particularly relevant in neuropsychiatry as many psychotropic medications possess anticholinergic properties that can worsen cognitive function, especially in elderly patients. The burden is often quantified using standardized scales to guide medication management and minimize cognitive side effects.
Usage
Usage note: Often abbreviated as ACB in clinical documentation.
In Context
- "The patient's anticholinergic burden was reduced by switching from amitriptyline to sertraline." — medication review report
- "High anticholinergic burden may contribute to delirium in hospitalized elderly patients." — clinical assessment
Also known as
anticholinergic load
anticholinergic toxicity
Don't confuse with
cholinergic crisis
anticholinesterase effect