cholinesterase inhibitor
Class of medications that block acetylcholinesterase enzyme to increase acetylcholine levels, primarily used in dementia treatment.
Full Definition
Cholinesterase inhibitors are a class of medications that work by blocking the acetylcholinesterase enzyme, which normally breaks down acetylcholine in the brain. By inhibiting this enzyme, these drugs increase the availability of acetylcholine, a neurotransmitter important for memory and cognitive function. The primary cholinesterase inhibitors used clinically include donepezil, rivastigmine, and galantamine, which are FDA-approved for treating mild to moderate Alzheimer's disease. These medications represent a key pharmacological approach in neuropsychiatry, though their benefits are typically modest and temporary. Editors must be familiar with this drug class when reviewing dementia research and treatment guidelines.
Usage
Usage note: Not to be confused with anticholinergic medications, which have opposite effects.
In Context
- "The patient was started on a cholinesterase inhibitor to address cognitive decline associated with Alzheimer's disease." — Treatment plan
- "Research suggests that cholinesterase inhibitors may provide modest benefits in Lewy body dementia." — Literature review