kindling
A neurobiological phenomenon where repeated subthreshold stimuli eventually lead to seizures or mood episodes.
Full Definition
Kindling is a neuroplastic process originally described in epilepsy research where repeated electrical stimulation of brain tissue at subthreshold levels eventually results in spontaneous seizures. In psychiatry, this concept has been applied to understand the progression of mood disorders, particularly bipolar disorder, where repeated episodes may lower the threshold for future episodes and reduce the effectiveness of treatment. The kindling hypothesis helps explain why early intervention and mood stabilization are crucial in preventing disease progression.
Usage
Usage note: When used in psychiatric contexts, often requires explanation of the original epilepsy research.
In Context
- "The kindling model suggests that untreated mood episodes may increase vulnerability to future episodes." — theoretical discussion
- "Kindling effects in temporal lobe epilepsy may explain the development of interictal psychiatric symptoms." — research paper