kindling
Progressive increase in seizure susceptibility following repeated subthreshold electrical stimulation.
Full Definition
Kindling is an experimental model of epileptogenesis where repeated application of initially subthreshold electrical stimuli to brain tissue eventually produces seizures and permanent increases in seizure susceptibility. This phenomenon demonstrates neuroplasticity in epilepsy development and has been crucial for understanding temporal lobe epilepsy mechanisms. In clinical research, kindling models help evaluate antiepileptic drugs and explore seizure prevention strategies. The term also applies to similar progressive sensitization phenomena in other neurological conditions.
Usage
Usage note: Specific neurological meaning distinct from general usage; primarily experimental context.
In Context
- "The amygdala kindling model reproduced key features of human temporal lobe epilepsy." — Preclinical research paper
- "Kindling protocols demonstrated the antiepileptogenic potential of early intervention." — Pharmacology study