carmustine wafer
Pronunciation: CAR-mus-teen
Biodegradable polymer wafer containing chemotherapy agent placed directly into the tumor cavity during surgery.
Full Definition
Carmustine wafers (brand name Gliadel) are biodegradable polymer discs impregnated with the chemotherapy drug carmustine (BCNU). These wafers are placed directly into the resection cavity during craniotomy to provide localized chemotherapy delivery while bypassing the blood-brain barrier. The wafers dissolve over 2-3 weeks, releasing carmustine directly to residual tumor cells. This treatment is used for both newly diagnosed and recurrent high-grade gliomas. Editorial considerations include proper spelling of 'carmustine' and understanding that this represents a specific drug delivery method, not just chemotherapy administration.
Usage
Usage note: Spell as 'carmustine,' not 'carmustene.' When referencing the brand name, capitalize 'Gliadel.'
In Context
- "Eight carmustine wafers were placed in the resection cavity following gross total resection." — Operative report
- "The patient developed localized edema consistent with carmustine wafer placement." — Post-operative note