ependymoma
Pronunciation: eh-PEN-di-moh-mah
A brain tumor arising from ependymal cells lining the ventricular system and central canal of the spinal cord.
Full Definition
Ependymoma is a neuroepithelial tumor originating from ependymal cells that line the brain ventricles and spinal cord central canal. These tumors are classified as WHO grades I, II, or III, with grade I (subependymoma and myxopapillary ependymoma) having the most favorable prognosis. Ependymomas commonly occur in the posterior fossa in children and in the spinal cord in adults. They frequently cause hydrocephalus when located near ventricular pathways and require complete surgical resection when feasible, followed by radiation therapy for higher-grade lesions.
Usage
Usage note: Distinguish from subependymoma, which is a distinct WHO grade I entity.
In Context
- "The fourth ventricular ependymoma was successfully resected without neurological deficit." — operative summary
- "Spinal ependymomas typically present with progressive myelopathy and require surgical decompression." — clinical review article