Stupp protocol
Standard treatment regimen combining radiation therapy with concurrent and adjuvant temozolomide for newly diagnosed glioblastoma.
Full Definition
The Stupp protocol, named after researcher Roger Stupp, is the established standard of care for newly diagnosed glioblastoma patients following maximal safe resection. The protocol consists of concurrent radiation therapy (60 Gy over 6 weeks) with daily temozolomide, followed by six cycles of adjuvant temozolomide. This regimen significantly improved survival outcomes when introduced in 2005. Editorial staff should note this is a proper noun requiring capitalization of 'Stupp' but not 'protocol,' and it appears frequently in treatment guidelines and clinical documentation.
Usage
Usage note: Capitalize 'Stupp' as it derives from the researcher's name, but keep 'protocol' lowercase unless beginning a sentence.
In Context
- "All patients with newly diagnosed glioblastoma received the Stupp protocol following surgical resection." — Clinical study methodology
- "The institutional guidelines mandate Stupp protocol initiation within six weeks of surgery." — Hospital policy document