tumor progression
Documented growth or worsening of a tumor based on imaging or clinical criteria, distinct from pseudoprogression.
Full Definition
Tumor progression refers to the measurable increase in tumor size, the appearance of new lesions, or clinical deterioration indicating tumor growth or spread. In neurosurgical oncology, this is typically assessed through serial MRI scans using standardized criteria such as RANO (Response Assessment in Neuro-Oncology) guidelines. True progression must be distinguished from pseudoprogression, which is a treatment-related inflammatory response that can mimic tumor growth on imaging. Accurate documentation of progression versus stable disease is critical for treatment decisions.
Usage
Usage note: Must be distinguished from pseudoprogression in post-treatment patients.
In Context
- "Serial MRI scans demonstrated clear tumor progression with a 40% increase in enhancing volume." — Radiology report
- "The patient showed clinical signs of tumor progression despite stable imaging." — Clinical assessment