vincristine
Pronunciation: /vɪnˈkrɪstiːn/
Also written as: VCR
A vinca alkaloid chemotherapy agent commonly used in pediatric brain tumor protocols, particularly for medulloepithelioma and ependymoma.
Full Definition
Vincristine is a plant-derived chemotherapy agent belonging to the vinca alkaloid class, widely used in pediatric neurosurgical oncology as part of combination chemotherapy regimens. The drug works by binding to tubulin and disrupting microtubule formation, thereby inhibiting cell division. In brain tumor treatment, vincristine is commonly used in protocols for medulloepithelioma, ependymoma, and low-grade gliomas, often in combination with other agents such as carboplatin or lomustine. The drug has limited ability to cross the blood-brain barrier but may be effective when this barrier is disrupted by tumor or surgery. Dose-limiting toxicity includes peripheral neuropathy, which can be cumulative and sometimes irreversible.
Usage
Usage note: Monitor for cumulative peripheral neuropathy with prolonged use.
In Context
- "The medulloepithelioma protocol included vincristine 1.5 mg/m² weekly during induction." — Chemotherapy regimen
- "Vincristine-induced peripheral neuropathy required dose modification in the maintenance phase." — Toxicity management note