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immunoreactive trypsinogen
Pancreatic enzyme precursor measured in newborn screening to detect cystic fibrosis through elevated levels.
Full Definition
Immunoreactive trypsinogen (IRT) is a pancreatic enzyme precursor that becomes elevated in newborns with cystic fibrosis due to pancreatic duct obstruction and inflammation. IRT serves as the primary screening marker for cystic fibrosis in most newborn screening programs. Elevated IRT levels trigger second-tier DNA testing or sweat chloride testing for confirmation. However, IRT levels can also be elevated in other conditions, requiring careful interpretation and appropriate follow-up protocols to minimize false positive results.
Usage
Usage note: May be abbreviated as IRT in laboratory contexts; spell out on first use.
In Context
- "Elevated immunoreactive trypsinogen triggered DNA analysis for cystic fibrosis mutations." — Laboratory report
- "The immunoreactive trypsinogen assay demonstrated excellent analytical performance in proficiency testing." — Quality assurance review
Also known as
IRT
Don't confuse with
trypsin
chymotrypsin
elastase