TSH
Pronunciation: T-S-H
Also written as: TSH — thyroid-stimulating hormone
Thyroid-stimulating hormone measured in newborn screening to detect congenital hypothyroidism.
Full Definition
TSH (thyroid-stimulating hormone) is a pituitary hormone measured from dried blood spots to screen for congenital hypothyroidism in newborns. Elevated TSH levels indicate insufficient thyroid hormone production, which can lead to intellectual disability and growth problems if untreated. The TSH screening test is highly effective, with most programs using age-specific cutoff values. Primary congenital hypothyroidism shows elevated TSH with low or normal thyroid hormones, while central hypothyroidism may show normal or low TSH levels.
Usage
Usage note: Always capitalize all three letters; never use 'Tsh' or 'tsh' in formal documentation.
In Context
- "The infant's TSH level was significantly elevated, prompting immediate endocrine consultation." — Clinical follow-up report
- "TSH screening has virtually eliminated intellectual disability from untreated congenital hypothyroidism." — Program outcome assessment