Levobupivacaine
Pronunciation: LEE-voh-BYOO-piv-uh-kayn
The S-enantiomer of bupivacaine with reduced cardiotoxicity, used for obstetric neuraxial anesthesia and analgesia.
Full Definition
Levobupivacaine is the pure S-enantiomer of bupivacaine, a long-acting amide local anesthetic developed to provide similar efficacy to bupivacaine with improved safety profile. It demonstrates significantly reduced potential for cardiotoxicity and central nervous system toxicity compared to racemic bupivacaine, making it particularly valuable in obstetric anesthesia where patient safety is paramount. The drug provides effective sensory and motor blockade for cesarean delivery and labor analgesia, with pharmacokinetic properties that make it suitable for continuous epidural infusions. Its improved therapeutic index has made it a preferred choice in many obstetric anesthesia practices worldwide.
Usage
Usage note: Should not be confused with racemic bupivacaine or dextrobupivacaine.
In Context
- "Levobupivacaine 0.125% was used for the epidural infusion to minimize motor block during labor." — Anesthetic record
- "The choice of levobupivacaine over bupivacaine was made to reduce the risk of cardiotoxicity." — Anesthetic consultation