Professional
Formal
IVT
Collaborative Ocular Melanoma Study
Landmark multi-center clinical trial that established treatment protocols for choroidal and ciliary body melanomas.
Full Definition
A comprehensive series of randomized clinical trials conducted from 1985-2003 that compared different treatment modalities for uveal melanomas. The study provided definitive evidence regarding the efficacy of enucleation versus plaque radiotherapy for medium-sized tumors and established standardized protocols for tumor measurement, treatment selection, and follow-up care. The COMS results fundamentally changed ocular oncology practice patterns worldwide.
Usage
Usage note: Often abbreviated as COMS in clinical documentation.
In Context
- "Treatment protocols were based on Collaborative Ocular Melanoma Study guidelines for medium-sized posterior uveal melanomas." — treatment planning documentation
- "The Collaborative Ocular Melanoma Study demonstrated equivalent survival outcomes between enucleation and plaque therapy." — literature review
Don't confuse with
COMS staging system
melanoma collaborative group