GEP
Pronunciation: G-E-P
Also written as: GEP — Gene Expression Profile
Gene Expression Profile testing used to assess metastatic risk in uveal melanoma patients.
Full Definition
Gene Expression Profile (GEP) testing is a molecular diagnostic assay that analyzes the expression levels of specific genes in uveal melanoma tissue to stratify patients into metastatic risk categories. The test examines a panel of genes whose expression patterns correlate with clinical outcomes, typically classifying tumors as Class 1 (low metastatic risk) or Class 2 (high metastatic risk). GEP testing has become an important prognostic tool that supplements traditional clinical and histopathologic factors in treatment planning and surveillance strategies. Results influence decisions regarding the frequency of metastatic monitoring and eligibility for adjuvant therapy trials.
Usage
Usage note: Results typically reported as 'Class 1' or 'Class 2' - capitalize 'Class' and use Arabic numerals.
In Context
- "GEP testing revealed a Class 2 profile, prompting intensified surveillance protocols." — Molecular pathology report
- "The patient's Class 1 GEP result was consistent with favorable prognosis." — Oncology consultation note