intraocular lymphoma
Primary or secondary lymphoma affecting intraocular structures, most commonly vitreoretinal lymphoma presenting as uveitis.
Full Definition
Intraocular lymphoma is a malignant lymphoid tumor that can arise primarily within the eye or secondarily from systemic lymphoma. The most common form is primary vitreoretinal lymphoma (PVRL), which is often associated with primary central nervous system lymphoma and typically presents as chronic uveitis that is refractory to corticosteroid treatment. Secondary intraocular lymphoma may arise from systemic non-Hodgkin lymphoma spreading to uveal or conjunctival tissues. Diagnosis requires cytological examination of vitreous or aqueous samples, and the condition has a poor prognosis if associated with CNS involvement.
Usage
Usage note: Often abbreviated as IOL in clinical notes, though this can be confused with intraocular lens - context is crucial.
In Context
- "The patient's chronic vitritis unresponsive to steroids raised suspicion for intraocular lymphoma." — Clinical case report
- "Vitreous biopsy confirmed the diagnosis of intraocular lymphoma with large B-cell morphology." — Pathology report